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Greater weight was given to longitudinal studies, systematic reviews, large population-based surveys, and well-controlled experimental or mechanistic studies, while evidence from cross-sectional or self-reported data was interpreted with caution

Dopamine is associated with pleasure and reward, which reinforces nicotines addictive nature

Honorary President of the Acadmie Royale Ligeoise de Billard

This reduced endurance often causes smokers to become less physically active, gradually creating a vicious cycle

The addictive nature of nicotine, coupled with the accessibility and social acceptance of cigarettes, contributes to the formidable challenge of quitting smoking [2]